MC5R is necessary for normal
sebum production. Stimulation of MC5R promotes
fatty acid oxidation in
skeletal muscle and lipolysis in
adipocytes. MC5R is essential for
erythrocyte differentiation. MC5R is involved in
inflammation. MC5R helps maintain
thermal homeostasis. Stimulation of the MC5R in skeletal muscle causes glucose uptake. In vitro, MC5R agonism is cardioprotective and kidney protective. MC5R is expressed in the brain at different levels depending on
physical activity.
Pheromones MC5R is heavily expressed in the
preputial gland in mice (a modified
sebaceous gland involved in
pheromone production). MC5R deficiency in male mice decreases aggressive behavior, promotes defensive behavior and encourages other male mice to attack MC5R-deficient males through pheromonal signals.
MRAP Melanocortin 2 receptor accessory protein (MRAP) traps MC5R protein inside cells. == Evolution ==