The Revenant was Nakehk'o's first film role. She was at the grocery store with her two young sons one Saturday morning when there was an open casting call in
Yellowknife, Northwest Territories. "People kept texting me and telling me I should go do this thing," she said. When the grocery store clerk also told her to try out for the role, she went to the casting call, arriving an hour before it was over. For her audition, Melaw had to improvise a scene with other actors about trading furs for a horse. "I didn’t have to read anything; it was all just presence and just being badass," she said. In a radio interview, Nakehk'o said she was impressed with film director
Alejandro G. Iñárritu's ability to bring out her acting ability in the role of Powaqa, an Arikara woman who is kidnapped by French
fur trappers, as well as with his accurate portrayal of
indigenous people. She has also said that the brutality with which her character is treated in the movie reflects
violence against indigenous women that is still going on today. For the red carpet premiere of the movie in
Hollywood, she received media attention when she wore a dress that was a collaboration between
Metis artist
Christi Belcourt and
Rome-based house of
Valentino. "It was really important to be able to represent Indigenous designers at such a high level of fashion, because today there’s a lot of
cultural appropriation with a lot of the huge fashion houses and people just being disrespectful wearing headdresses and
Native American-inspired stuff," Nakehk'o stated. ==Cultural activities==