Musical career During her career as a telenovela actress, in 2013, she was part of the duet Melissa y Sebastian with Sebastian Martingaste, with whom she released her first album and had her first top ten radio hit with their debut single "Mamma Maria", which is a cover of
Ricchi e Poveri's 1982 song of the same name under the TV Azteca label. In 2015, she released the theme song "Volver a caer" alongside
Kalimba for
Tanto amor. In 2020, she joined Gracias Uniwerso, which she released her debut single as a solo artist,
Stay Home With Me. The song was born during the quarantine period when Barrera found herself with unexpected time for self-reflection. The lyrics reflect on how lives returned to a different pace "faster than we thought" and offers a message of finding magic and a "second chance" despite the pain and fear of the dark. She shared it on Instagram with the note, "I wrote a song. I hope you like it". Thematically, it captures the feeling of life abruptly shifting from a fast-paced career to a sudden standstill. In 2021, she released
Una y Otra Vez which features her sisters, Rosanna, Regina and Mayelah. Written by Melissa and Marcela De La Garza, the lyrics focus on the enduring nature of love and choice, with the title translating to "Again and Again" or "Over and Over". Melissa has noted that if she had to choose her life or family again, she would choose them "una y otra vez". It was released shortly before her breakout international film role in
In the Heights, marking a moment where she returned to her musical roots in Mexico before her global stardom accelerated. Three months later, she starred in and released her debut soundtrack album
In the Heights under
Atlantic Records. The same year, she recorded the soundtrack album
Carmen, in collaboration with composer Nicholas Britell and singer-songwriter Julieta Venegas, and was released on 21 April 2023 under
Sony Masterworks. On February 2023, she recorded the soundtrack album
Your Monster, and a year later, it was released on 25 October 2024 under
Vertical.
Activism and philanthropy In November 2023, it was reported that Barrera had been dropped from her lead role in the upcoming sequel
Scream 7. The firing was a result of social media posts she had made which described Gaza as a "
concentration camp" and
the Israeli government's actions in the
Gaza war as "
genocide and
ethnic cleansing". In addition, she shared a magazine article from
Jewish Currents, penned by Israeli historian and genocide scholar
Raz Segal, alleging the Israeli government was distorting “the Holocaust to boost the Israeli arms industry”, which was deemed antisemitic by
Spyglass. In late 2023, a Spyglass spokesman told
Variety "Spyglass’ stance is unequivocally clear: We have zero tolerance for antisemitism or the incitement of hate in any form, including false references to genocide, ethnic cleansing, Holocaust distortion or anything that flagrantly crosses the line into hate speech.” Following her firing, Barrera released a statement which denounced
antisemitism and
Islamophobia and said criticism of a government should not be conflated with attacks on the people of a country. Barrera described the year following the firing to be a downturn in opportunities to work, and stated: In January 2024, she participated in a
protest against the
genocide in Palestine at the
Sundance Film Festival. She amplified her advocacy by encouraging donations to the United Nations Relief and Works Agency for Palestine Refugees in the Near East (
UNRWA), that raised over $60,000 for Palestinian refugees drawing both support and controversy. She also uses her platform to promote
Doctors Without Borders and
Save the Children, and she is a recurring volunteer at the Central Texas Food Bank, where she helps address local food insecurity. Staff and community members have praised her for being a hands-on volunteer who seeks to help rather than just appear for "photo ops". In September 2025, Barrera was among more than 5,000 film industry professionals to sign a pledge organized by
Film Workers for Palestine. The signatories committed to a boycott of Israeli film and television institutions accused of being "complicit in the occupation" of Palestine. The pledge specifically includes a refusal to collaborate with production companies, film festivals, and distributors that are funded by the Israeli government or that "whitewash" its policies. According to
The Hollywood Reporter, the boycott targets state-linked institutions rather than individual Israeli filmmakers.
Screenwriting and directing In April 2025, Barrera revealed she had completed the screenplay for a lesbian romantic comedy, which she also intends to direct. She has expressed a desire to move beyond her established "scream queen" reputation to focus on original content and indie cinema. Her expanding role behind the camera includes serving as an executive producer with
John Leguizamo on the documentary
Traces of Home (2025).
Endorsements In June 2021, Barrera was named the first Latina Global Ambassador for the cosmetics company
Clinique. She has also participated in campaigns for skincare brand Kiehl's. In addition to her role with Clinique Barrera has established a consistent presence in high fashion through recurring collaborations with several luxury houses. She has been frequently styled in
Versace, notably wearing the brand for the 2023 CinemaCon Big Screen Achievement Awards and during her press tour for
Scream VI. Additionally, she has a long-standing relationship with the luxury footwear brand Aquazzura, which has provided custom footwear for her international film premieres, including the 2023
Scream VI tour. Her fashion choices are often documented by industry outlets such as Red Carpet Fashion Awards, which track her transition toward high-luxury labels for her public appearances. Barrera has maintained a long-standing relationship with the luxury fashion house
Chanel, frequently appearing as a guest at the brand's fashion shows and events. In late 2025, Barrera significantly expanded her fashion portfolio by becoming a central figure for the Italian luxury house
Roberto Cavalli. She was selected as the face of the brand's Fall/Winter 2025-26 campaign, appearing in global advertisements and digital content. Her partnership with the house was further highlighted during the press tour for The Copenhagen Test, where she was exclusively dressed by the brand for the New York City premiere. Industry analysts have noted that her association with Cavalli aligns with her transition from "scream queen" to a high-fashion red carpet fixture. Barrera has maintained a long-standing partnership with
Armani Beauty, serving as a frequent brand partner for their global cosmetics campaigns. She has prominently featured in promotions for the brand’s signature products, including the Luminous Silk Foundation and Eye Tint lines. In December 2024, she detailed her extensive history with the brand in a profile for
Into The Gloss, noting that Armani has been her primary beauty collaborator for her international film press tours and festival appearances, including the Sundance Film Festival, and a long-standing association with
NARS Cosmetics, often featuring the brand's products as staples in her professional and personal beauty routines. ==Personal life==