She started training for the Cienfuegos team at the age of 12, also played in the
Cuban national youth volleyball teams. She played for
Agel Prostějov in the
Czech Republic for one season in 2016. She suffered a shoulder injury and returned to her country for treatment. After she was dissatisfied with the treatment opportunities in her country and criticized them, she was banned from playing in the national team for 4 years between 2017–2021, on the grounds of indiscipline. Then she was transferred to
Volero Zürich.
Fenerbahçe (2018–present) On 29 June 2018, she was transferred to
Turkey for
Fenerbahçe Opet and started her career as a fairy tale. She played in the Chinese League in the first halves of the Sultans League in the 2021, 2022 and 2023 seasons and returned to Fenerbahçe for the second halves of those seasons. On 10 April 2021, the application made by the
Turkish Volleyball Federation for Vargas to obtain citizenship of the
Republic of Turkey was approved and
President Recep Tayyip Erdoğan presented Melissa Vargas with her TR ID Card. On 9 July 2024, she renewed her contract with Fenerbahçe Opet for 3 years. == International career ==