Originally scheduled to open for the 2017–18 school year, Memorial High School's opening was delayed due to budget cuts, along with Lawler Middle School and Liscano and Talley elementary schools.
Heritage,
Lone Star, and
Wakeland high schools were affected by crowding issues with larger classroom sizes, which were fixed with the opening of Memorial High School. The Class of 2022 in Memorial High School had several members who conspired to create a devious prank which inflicted thousands of dollars of damage upon the school. A group of senior classmen got official approval for a sticky-note prank on the second to last day of school. They were supposed to place the sticky-notes on the walls of the school during the morning but instead overpowered the teachers and started spraying fire extinguishers in the school in addition to other damage-causing actions. This incident led to the cancellation of school for the last 2 days. Meanwhile, Memorial High School got a lot of local media coverage due to the incident. On April 2, 2025, Frisco Memorial football player
Austin Metcalf was stabbed to death at the 11-5A UIL track meet at
Kuykendall Stadium. A student by the name of
Karmelo Anthony at
Frisco Centennial was arrested by police and has been charged with first degree murder. ==Athletics==