In 1910, at the age of 13, she ran away from home to live on
Beale Street in Memphis. She played on street corners for most of her teenaged years, occasionally returning to her family's farm when she ran out of money. Her sidewalk performances led to a tour of the South with the
Ringling Brothers Circus from 1916 to 1920. Minnie's early musical development reflected the broader Southern country blues, highlighting the tradition with which she had grown up. As David Evan notes in
Big Road Blues, performers from the Mississippi Delta and other regions combined a mixture of dance rhythms, melodic phrasing, and storytelling of Black rural culture, all of which are elements that are audible in Minnie's early guitar and vocal work. By adapting and reshaping this style, she became one of the performers who helped define the emerging country blues for later generations. She then went back to Beale Street, with its thriving blues scene, and made her living by playing guitar and singing, supplementing her income with prostitution. She began performing with
Kansas Joe McCoy, her second husband, in 1929. They were discovered by a talent scout for
Columbia Records, in front of a barber shop, where they were playing for dimes. McCoy and she went to record in New York City and were given the names Kansas Joe and Memphis Minnie by a Columbia A&R man. Over the next few years, McCoy and she released a series of records, performing as a duet. In February 1930, they recorded the song "Bumble Bee" for the
Vocalion label, which they had already recorded for Columbia, but which had not yet been released. It became one of Minnie's most popular songs; she eventually recorded five versions of it. Minnie and McCoy continued to record for Vocalion until August 1934, when they recorded a few sessions for
Decca Records. Their last session together was for Decca, in September. They divorced in 1935. Her vocal confidence and commanding stage presence established her as a role model influencing generations of female blues artists. Paul and Beth Garon, in their biography ''Woman with Guitar: Memphis Minnie's Blues'', suggested that Broonzy's account may have combined various contests at different dates, as these songs of Minnie's date from the 1940s rather than the 1930s. By 1935, Minnie was established in Chicago and had become one of a group of musicians who worked regularly for the record producer and talent scout
Lester Melrose. Back on her own after her divorce from McCoy, Minnie began to experiment with different styles and sounds. She recorded four sides for
Bluebird Records in July 1935, returned to the Vocalion label in August, and then recorded another session for Bluebird in October, this time accompanied by
Casey Bill Weldon, her first husband. By the end of the 1930s, in addition to her output for Vocalion, she had recorded nearly 20 sides for Decca and eight sides for Bluebird. and in May of that year, she recorded her biggest hit, "Me and My Chauffeur Blues". Minnie's adoption of electric guitar placed her at the forefront of the stylistic shift in blues. Sonnet Retman describes her amplified playing as part of an emerging "Afro-Sonic modernity", where musicians combined aspects of rural country blues with the new electric sound. Her articulation, rythmic drive, and experimentation with amplification of the electric guitar bridged the acoustic country traditions in which she grew up, in tandem with the postwar electric blues, encouraging younger Chicago players who followed suit. Minnie often played at "Blue Monday" parties at Ruby Lee Gatewood's, on Lake Street. The poet
Langston Hughes, who saw her perform at the 230 Club on New Year's Eve, 1942, wrote of her "hard and strong voice" being made harder and stronger by amplification and described the sound of her electric guitar as "a musical version of electric welders plus a rolling mill." Later in the 1940s, Minnie lived in
Indianapolis and
Detroit. She returned to Chicago in the early 1950s.{{cite book ==Later life and death==