The area around Mendefera evolved into an important region in the
Aksumite civilisation. Though satisfactory excavations have not yet been made, a graveyard dating back to the 2nd century BCE has been found. It contained skeletons, pottery, necklace and bronze bracelets. Numerous buildings have been excavated since 1959, with both
crosses and local and
Roman coins found. Many areas, including
tombs, have yet to be explored. The modern town of Mendefera was built during the Italian era. The town is now bustling market town in a fertile region of Eritrea. It is a place where small and large scale factories produce different products. Mendefera is famous for its anticolonial movement during the Italian colonial administration and is a great fighter contributor of the
Eritrean Liberation Front (ELF) as it is home to one of the oldest schools in Eritrea,
San Giorgio School. ==Climate==