Her research interests include computational and theoretical
plasma physics in space and
astrophysics, interaction of the
Solar System with the
interstellar medium,
solar wind, and shocks in the lower corona, T-Tauri and Solar-Like Stars. In 2001, Opher began work on the heliosphere while she was a postdoctoral student at the Jet Propulsion lab. Her researcher focuses on how the solar wind shapes the heliosphere, the protective atmospheric shield between Earth and the rest of the galaxy, where she has shown the shape of the heliosphere is similar to a croissant and not a comet with a tail as previously thought. Opher's 2020 paper expanding on the crescent shape of the heliosphere was published in
Nature Astronomy, featured on the cover of the July 2020 issue, and covered by the media. In 2021, Opher's research revealed that the stability of the heliosphere originates from the neutral hydrogen particles that interact with the heliosphere. Opher has written in
The Hill about the dangers of space tourism for people where she describes the radiation coming through space and the need to better understand how the heliosphere filters this radiation before people can travel safely to other planets. As of 2021, Opher's research has been cited more than 4400 times and she has an
h-index of 37. ==Honors and awards==