The term "metahuman" was first used by the
Dominators, an alien species who attacked Earth during the 1988 series
Invasion! Origins DC Comics presents two conflicting accounts of the origins of the metagene. The 1995
Xenobrood mini-series shows the alien Vimanian race claim credit for the introduction of superpowered alien genetic matter into human
DNA. The Vimanians forced their super powered worker drones to mate with humanity's ancestors
Australopithecus afarensis and
Homo erectus to create a race of superpowered slaves. Later, in
Road to Dark Nights: Metal (2017), the
Joker revealed to
Duke Thomas that the term "meta" originated from a rudimentary hospital program used to automatically flag
Nth Metal toxicity found in a person's bloodstream, similar to iron or zinc, with "meta" being short for "metal". This natural toxicity is the "variant" that changes the individual's DNA results in the metagene and its various heightened abilities and powers.
Metahuman as classification The terms "meta" and "metahuman" do not refer only to humans born with biological variants. It can refer to anyone with intrinsic extraordinary powers, no matter the origins, and including those not born with such power.
Superman and
Martian Manhunter (aliens) as well as
Wonder Woman (a near-goddess) and
Aquaman (an
Atlantean) are referred to in many instances as metahumans. According to
Countdown to Infinite Crisis, roughly 1.3 million metahumans live on Earth, 99.5% of whom are considered "nuisance-level". The other 0.5% are what
Checkmate considers alpha-, beta- and gamma-level threats. For example, Superman and Wonder Woman are categorized as alpha-level, while
Metamorpho is considered a beta-level and
Ratcatcher is considered gamma-level. In 2026, the DC Comics website stated that metahuman was a label rather than a stable taxonomic category: "If you’re looking for consistent parameters on what does or doesn’t count as a metahuman, you’re not gonna find them." Within the comics, the editorial stated that whether bneing a metahuman was defined by "the scope of the powers or their nature... depends who you ask". Specifically in relation to the films and TV series, it said "The line seems to be drawn at intrinsic powers versus extrinsic powers. If your powers come from an accessory you can take on and off, you’re not a metahuman. But if you have a cybernetic implant, that does classify you as a metahuman."
Exo-gene The
52 miniseries introduced a toxic mutagen called the Exo-gene (also referred to as the Exogene). It is a toxic
gene therapy treatment created by
LexCorp for the
Everyman Project, which creates metahuman abilities in compatible non-metahumans. The project was controversial, creating unstable heroes that gave Luthor an "off switch" for their powers, creating countless mid-flight deaths. ==Marvel Comics==