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Methionine–tRNA ligase

In enzymology, a methionine–tRNA ligase is an enzyme that catalyzes the chemical reactionATP + L-methionine + tRNAMet AMP + diphosphate + L-methionyl-tRNAMet

Role in oxidative stress
During oxidative stress, methionine–tRNA ligase might be phosphorylated, which results in promiscuity of this enzyme, where it aminoacylates methionine to various non-Met tRNAs. This in turn leads to substitution of amino acids in proteins with methionine, which helps relieve oxidative stress in the cell. ==Structural studies==
Structural studies
As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , , , , , , , , and . == References ==
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