Metro opened in 1972 in a five-room building at 2135 Chouteau Avenue as an
alternative public high school. It became one of the first
magnet schools in the St. Louis Public Schools district in 1981. In the early 1980s, the school moved to the
Temple Israel building at 5017 Washington Place and in 1996, it moved to its current location in a purpose-built school building. Her replacement, Pamela Randall, served until 2003, when she entered district administration and later served as acting superintendent of the St. Louis Public Schools. Randall's replacement, Wilfred Doug Moore, was principal from 2003 to 2017, followed by Steven Lawler. In 2022, Lawler retired as the principal of Metro, and Dr. Tina Wallace-Hamilton became Metro's principal at the start of the 2022-23 school year. All Metro students are required to perform 250 hours of community service prior to graduation, previously 200. Metro has been ranked among the top public high schools by
Newsweek and has won national and state-level awards for quality. For the 2003–2004 school year, Metro was named a Missouri Gold Star school and a national
Blue Ribbon school. It was again named a Missouri Gold Star school and Blue Ribbon school in 2007–2008. In 2016, the school earned the top scores for Missouri end-of-course exams in English, science, and social studies in the state. In May 2018, Metro earned the top ranking in the state. In May 2020, Metro was ranked #1 high school in the state of Missouri and #114 nationally by
U.S. News & World Report. It has remained #1 in the state since. In May 2023, Metro was ranked #99 in National rankings. == Notable alumni ==