The metrological gain is, in general, the gain in sensitivity of a quantum state compared to a product state. Metrological gains up to 100 are reported in experiments. Let us consider a
unitary dynamics with a parameter \theta from initial state \varrho_0, :\varrho(\theta)=\exp(-iA\theta)\varrho_0\exp(+iA\theta), the
quantum Fisher information F_{\rm Q} constrains the achievable precision in statistical estimation of the parameter \theta via the
quantum Cramér–Rao bound as :(\Delta \theta)^2 \ge \frac 1 {m F_{\rm Q}[\varrho,A]}, where m is the number of independent repetitions. For the formula, one can see that the larger the quantum Fisher information, the smaller can be the uncertainty of the parameter estimation. For a multiparticle system of N spin-1/2 particles :F_{\rm Q}[\varrho, J_z] \le N holds for separable states, where F_{\rm Q} is the quantum Fisher information, : J_z=\sum_{n=1}^N j_z^{(n)}, and j_z^{(n)} is a single particle
angular momentum component. Thus, the metrological gain can be characterize by :\frac{F_{\rm Q}[\varrho, J_z]}{N}. The maximum for general quantum states is given by :F_{\rm Q}[\varrho, J_z] \le N^2. Hence,
quantum entanglement is needed to reach the maximum precision in
quantum metrology. Moreover, for quantum states with an
entanglement depth k, :F_{\rm Q}[\varrho, J_z] \le sk^2 + r^{2} holds, where s=\lfloor N/k \rfloor is the largest integer smaller than or equal to N/k, and r=N-sk is the remainder from dividing N by k. Hence, a higher and higher levels of
multipartite entanglement is needed to achieve a better and better accuracy in parameter estimation. It is possible to obtain a weaker but simpler bound :F_{\rm Q}[\varrho, J_z] \le Nk. Hence, a lower bound on the entanglement depth is obtained as :\frac{F_{\rm Q}[\varrho, J_z]}{N} \le k. == Mathematical definition for a system of qudits ==