His research focuses on the development of mathematical models, such as the
Mackey-Glass equations, to describe physiological processes at the cellular and molecular levels as well as foundational questions in physics related to the nature of
irreversibility,
entropy, and the
arrow of time. He developed, with
Leon Glass, the concept of dynamical disease in which a parameter change in a physiological control system is hypothesized to lead to pathological behavior, and the use of
chaos theory to investigate such possibilities. == References ==