Egnor rejected
evolutionary theory after reading
Michael Denton's book
Evolution: A Theory in Crisis and said "claims of evolutionary biologists go wildly beyond the evidence." In 2007 he joined the Discovery Institute's
Evolution News & Views blog. Biologist
Jerry Coyne responded to Egnor's article by saying that Egnor accepted widely discredited claims (claims recanted by Denton himself in a later book) and "Egnor is decades out of date and shows no sign of knowing anything at all about evolutionary biology in the 21st century." Egnor later published a series of comprehensive articles on Discovery Institute responding to Coyne's remarks. Egnor is a signatory to the
Discovery Institute intelligent design campaign A Scientific Dissent From Darwinism and
Physicians and Surgeons who Dissent from Darwinism. In March 2007, when the Alliance for Science sponsored an essay contest for high school students on the topic "Why I would want my doctor to have studied evolution," Egnor responded by posting an essay on the
Discovery Institute's intelligent design blog claiming that evolution was irrelevant to medicine. Burt Humburg criticized him on the blog
Panda's Thumb citing the benefits of evolution to medicine and, contrary to Egnor's claim, that doctors, that is physicians in this case, do study evolution. Egnor appeared in
Expelled: No Intelligence Allowed. In the film,
Ben Stein describes this as "Darwinists were quick to try and exterminate this new threat," and Egnor says he was shocked by the "viciousness" and "baseness" of the response. The website
Expelled Exposed, created by the
National Center for Science Education (NCSE), responded by saying that Egnor must never have been on the Internet before. In September 2021 Egnor debated
Matt Dillahunty. ==Aristotelian dualism==