Leaded gasoline anti-knock compound Ethyl, a
gasoline additive In 1916, Midgley began working at
General Motors. In December 1921, while working under the direction of
Charles Kettering at
Dayton Research Laboratories, a subsidiary of General Motors, he discovered (after discarding
tellurium due to the difficult-to-eradicate smell) that the addition of
tetraethyllead (TEL) to gasoline prevented
knocking in
internal combustion engines. The company named the substance "Ethyl", avoiding all mention of lead in reports and advertising.
Oil companies and
automobile manufacturers (especially General Motors, which owned the patent jointly filed by Kettering and Midgley) promoted the TEL additive as an inexpensive alternative superior to
ethanol or
ethanol-blended fuels, on which they could make very little profit. In December 1922, the
American Chemical Society awarded Midgley the 1923
Nichols Medal for the "Use of Anti-Knock Compounds in Motor Fuels". This was the first of several major awards he earned during his career. That year, General Motors created the General Motors Chemical Company (GMCC) to supervise the production of TEL by the
DuPont company. Kettering was elected as president with Midgley as vice president. However, after two deaths and several cases of lead poisoning at the TEL prototype plant in
Dayton, Ohio, the staff at Dayton was said in 1924 to be "depressed to the point of considering giving up the whole tetraethyl lead program". while efforts to limit lead's use date back to at least the 16th century. Midgley experienced lead poisoning himself, and was warned about the risk of lead poisoning from TEL as early as 1922. Midgley knew well the hazards of lead. He investigated whether the risks, both in production and use, could be managed. Testing on the exhaust was completed, which he used to support the idea that 1 part tetraethyl lead per 1300 of gasoline could safely be used. After the initial worker exposures, controls were developed to allow the process to operate safely. Leaded gasoline use grew exponentially. The cumulative chronic impacts of environmental lead were grossly underestimated. On October 30, 1924, Midgley participated in a
press conference to demonstrate the apparent safety of TEL, in which he poured TEL over his hands, placed a bottle of the chemical under his nose, and inhaled its
vapor for sixty seconds, declaring that he could do this every day without succumbing to any problems. However, the state of New Jersey ordered the Bayway plant to be closed a few days later, and Jersey Standard was forbidden to manufacture TEL again without state permission. Production was restarted in 1926 after intervention by the federal government; High-octane fuel, enabled by lead, was of military importance. Midgley later took a leave of absence from work after being diagnosed with lead poisoning. He was relieved of his position as vice president of GMCC in April 1925, reportedly due to his inexperience in organizational matters, but he remained an employee of General Motors. Midgley, working with
Albert Leon Henne, soon narrowed his focus to alkyl halides (the combination of carbon chains and
halogens), which were known to be highly
volatile (a requirement for a refrigerant) and also
chemically inert. They eventually settled on the concept of
incorporating fluorine into a
hydrocarbon. They rejected the assumption that such compounds would be toxic, believing that the stability of the
carbon–fluorine bond would be sufficient to prevent the release of
hydrogen fluoride or other potential
breakdown products. the first
chlorofluorocarbon (CFC), which they named "
Freon". This compound is more commonly referred to today as "Freon 12", or "
R12". Freon and other CFCs soon largely replaced other refrigerants, but also had other applications. A notable example was their use as a propellant in
aerosol products and
asthma inhalers. The
Society of Chemical Industry awarded Midgley the
Perkin Medal in 1937 for this work. In 1941, the
American Chemical Society gave Midgley its highest award, the
Priestley Medal. This was followed by the
Willard Gibbs Award in 1942. He also held two
honorary degrees and was elected to the
United States National Academy of Sciences. In 1944, he was elected president and chairman of the American Chemical Society. == Death ==