The league was founded by four clubs which were all previously members of the
United Premier Soccer League Midwest Conference. Following the 2019 UPSL season, the clubs decided that they could create a stable league that would focus on sustainability of the member clubs by sharing ideas, keeping league costs to a minimum, and maximizing the opportunities for all clubs to compete by limiting end-of-season playoffs that often shorten the season for many teams. The league announced
Union Dubuque F.C. as its first member on September 18, 2019, with the other three founding members being announced in the subsequent weeks. RWB Adria joins the MPWL on September 25, 2019. DeKalb County United joins the MWPL on October 2, 2019. Cedar Rapids Inferno join the MWPL on October 9, 2019 making it the fourth member team. And concludes the joining of the founders. Cliff Conrad has been elected as the league's first president. Conrad is the co-founder and president of Union Dubuque F.C., one of the league's charter members. After a period with no expansion news,
FC Diablos of
Normal, Illinois, was announced on January 10, 2020, and an expansion continues into March. With expansion side
Rockford FC being unveiled shortly thereafter on January 30, 2020. Livonia City FC joins the MWPL on Feb. 29th 2020. Lake St.Clair joins the MWPL on March 2, 2020. BiH Grand Rapids joins the MWPL on March 6, 2020. The league was set to kick off in spring 2020; however, the season was cancelled due to the
COVID-19 pandemic in the United States. The Midwest Premier League appoints Andy Hayes as the league's first commissioner. On July 27, 2020, the league announced
Lansing Common FC from
Lansing, Michigan, as a new member club. On September 3, 2020, the MWPL entered a partnership agreement with the
National Independent Soccer Association, a
USSF Division 3 professional league, which includes pathways for both players and clubs to go fully pro. November 2020 kicked off another round of expansions for the league. Starting with
Edgewater Castle FC on Nov. 27th 2020. In the spring of 2021 MWPL launched its inaugural season with 20 teams in two divisions. 12 teams in the West Division and 8 teams in the East Division. It was announced on March 21, 2022 that the MWPL would have 3 Divisions within it. The schedule for the second season of the league was announced on April 6, 2022, nearly a month ahead of the first game. With Detroit City U23 gone, there would be a new champion in the East Division. And with a finalized Southern Division, 3 champions were to be crowned at the end of the 2022 season. A new conference alignment was announced by the league on February 6, 2023. The MWPL confirmed that for the 2023 season, the South Conference would now be known as the Gateway Conference, the West Conference would now be the Heartland Conference and the East Conference would be the Great Lakes Conference, with an East and West Division. On October 27, 2023 MWPL announced plans to implement promotion and regulation within the league starting with the Heartland Conference. MWPL announced a strategic partnership with
The League for Clubs (TLFC) on May 19, 2025. The partnership is intended to create a new TLFC Midwest conference that will sit on top of the MWPL to facilitate promotion and relegation between the leagues. ==Teams==