Due to growing maltreatment of the Armenians in the Ottoman Empire, Mesrobian decided to move to the United States in the early 1920s. With the allowance of Armenians immigrants into the United States reaching its limit, Mesrobian was given special permission to enter the country by the
Secretary of Labor due to his expertise in architecture. The project also included another housing development near Woodley Park called the Cathedral Mansions off
Connecticut Avenue. The hotel was eventually resold in 1953 to
Sheraton Hotels, which renamed the hotel the Sheraton-Carlton Hotel. Immediately after the success of the Carlton Hotel, Harry Wardman planned another hotel near the site where the 1885 homes of
John Hay and
Henry Adams once stood at 16th and
H Streets NW. The building was done in an
Italian Renaissance style and it featured
Ionic,
Doric, and
Corinthian columns of the classical Greek era. Wardman was forced to sell the hotel in 1931, due to the Great Depression, to Washington Properties. Mesrobian became an American citizen when he was naturalized in 1927. Nevertheless, Mesrobian continued designing for Wardman until his death in 1938. In 1940, Mesrobian designed the
Glebe Center, also known as Glebe Shopping Center located in the
Ballston neighborhood of
Arlington County,
Virginia. It is a one-story, L-shaped cinder-block building with a flat parapet roof and clad in a six-course, American-bond brick veneer with cast-stone decorative accents. It features large store-front windows,
Art Deco decorative elements, and a central square tower surmounted by a glass-block
clerestory capped by a pyramidal-shaped metal roof. It was built to serve the residents of the
Buckingham apartment complex and
Ashton Heights, as well as the many motorists traveling along Arlington Boulevard and North Glebe Road. It was listed on the
National Register of Historic Places in 2004. In 1943, Mesrobian designed the Wakefield Manor, a garden apartment complex located at 1215 N. Courthouse Road in Arlington. The design of the building incorporates an art-deco and moderne style and was built under standards promoted by the
Federal Housing Administration (FHA). Though Mesrobian was the architect behind the apartment, he held its ownership. It was added to the
National Register of Historic Places on 15 December 1997. The Calvert Manor also was awarded the Arlington County Preservation Design Award in 2002. It was listed on the
National Register of Historic Places in 2004. Mihran Mesrobian retired in the early 1950s and lived in
7410 Connecticut Avenue in
Chevy Chase,
Maryland in a house he designed himself in 1941. The house is a two-story building made of brick and includes a pavilion that transforms into a porch. The front facade is asymmetrical with a wall of glass on the right and the front door on the left. Mesrobian lived in the house until his death in 1975. It was then listed on the
National Register of Historic Places in 2017. ==Later life and death==