He got his start working for trainer Odie Clelland as a stable hand then began riding professionally in 1959 and earned his first win on March 3, 1960, at
Fair Grounds Race Course in
New Orleans. On June 25, 1964, he rode five straight winners at Ohio's
Thistledown Racecourse. He was a long-time fan favorite at
Florida Downs in
Oldsmar, Florida where he won four races on a single day on February 15, 1968, set a season record with 75 wins in 1969, and by 1975 had won six riding titles.A record that has not been surpassed as of 2023. His five wins in the
Turfway Park Fall Championship Stakes is the most by any jockey as of 2023 . In 1970, Mike Manganello won the
Blue Grass Stakes at
Keeneland Race Course in
Lexington, Kentucky aboard
Dust Commander then rode the colt to a commanding five-length victory in the most prestigious race in American
horse racing, the
Kentucky Derby. In addition to winning the
1970 Kentucky Derby, Manganello also had mounts in
1969,
1971,
1972 and in
1974. He was the leading stakes rider in 1968. ==Retirement==