Zeck began his comics career in 1974, doing illustration assignments for the text stories in
Charlton Comics' animated line of comics, which led to work on their horror titles. Zeck later worked on
Captain America and drew covers for
G.I. Joe: A Real American Hero. Zeck illustrated the
Marvel Super-Heroes Secret Wars limited series in 1984. For this series, he designed a new black-and-white costume temporarily worn by Spider-Man. The plot that developed as a result of Spider-Man's acquisition of the costume led to the creation of the Spider-Man villain
Venom. In 1986, Zeck collaborated with writer
Steven Grant on a
Punisher miniseries, which was later collected as
The Punisher: Circle Of Blood and an original hardcover graphic novel of the character three years later. Zeck illustrated the 1987
Spider-Man storyline "
Kraven's Last Hunt", written by his former
Captain America collaborator
J. M. DeMatteis, which is considered to be one of the quintessential stories in Spider-Man's history, as well as the definitive
Kraven the Hunter storyline. DeMatteis remarked, "Because Mike nailed the plot elements so perfectly in his pencils—every action, every emotion, was there, clear as a bell — I didn't have to worry about belaboring those elements in the captions or dialogue. I was free to do those interior monologues that were so important to the story. If any other artist had drawn “Kraven's Last Hunt” ... it wouldn't have been the same story." In 2004, Zeck's cover of
Web of Spider-Man #32, which depicts Spider-Man escaping the grave into which he has been interred by Kraven, was recreated as a 12-inch-tall resin diorama statue by
Dynamic Forces. Zeck has worked for DC Comics as well. He contributed to ''
Who's Who: The Definitive Directory of the DC Universe in the mid-1980s. Zeck drew the covers for the "Ten Nights of the Beast" storyline in Batman #417–420 (March–June 1988) and these covers were later collected in a portfolio. His other credits for the publisher include Batman: Legends of the Dark Knight, Legends of the DC Universe
, and covers for Deathstroke, The Terminator. In 1999, he collaborated with writer Mark Waid on The Kingdom (illustrating issue #2, with Ariel Olivetti illustrating issue #1), a sequel to Kingdom Come''. ==Later life==