Philadelphia Eagles 2019 Sanders was selected by the
Philadelphia Eagles in the second round (53rd overall pick) of the
2019 NFL draft. He was represented by Beyond Athlete Management. Sanders made his NFL debut in Week 1 against the
Washington Redskins. In the game, Sanders rushed 11 times for 25 yards, and the Eagles won 32–27. In Week 6 against the
Minnesota Vikings, Sanders rushed three times for six yards and caught three passes for 86 yards and a touchdown. In the Week 15 rematch against Washington, Sanders rushed 19 times for 122 yards and a touchdown and also caught six passes for 50 yards and another touchdown in a 37–27 win. During the game, Sanders passed
LeSean McCoy and
DeSean Jackson for the most rushing yards by a rookie and the most all-purpose yards by a rookie in franchise history, respectively. In Week 16 against the
Dallas Cowboys, Sanders rushed 20 times for 79 yards and a touchdown and caught five passes for 77 yards. He finished his rookie season with 818 rushing yards and three rushing touchdowns to go along with 50 receptions for 509 receiving yards and three receiving touchdowns. He was named to the
PFWA All-Rookie Team. In the
National Football Conference (NFC)
Wild Card Round against the
Seattle Seahawks, Sanders rushed 14 times for 69 yards in Philadelphia's 17–9 loss.
2020 Sanders missed the first game of the 2020 regular season with a hamstring injury. He returned in Week 2 to make his season debut against the
Los Angeles Rams. In the 37–19 loss, Sanders recorded 131 scrimmage yards and a rushing touchdown. In Week 5 against his hometown team, the
Pittsburgh Steelers, Sanders rushed for 80 yards and two touchdowns, including a 74-yard score, during a 38–29 loss. In Week 6 against the
Baltimore Ravens, he had nine carries for 118 yards. In Week 14, against the
New Orleans Saints, he had fourteen carries for 115 yards and two touchdowns, including a career-high 82-yard score, during the 24–21 win. Sanders played in 12 games in the 2020 season. He finished with 164 carries for 867 rushing yards and six rushing touchdowns to go along with 28 receptions for 197 receiving yards. Following the season, Sanders, along with
Clyde Edwards-Helaire were selected to the playable Pro Bowl roster of the Madden 21 Video Game Numbers Challenge.
2021 While Sanders started off as the team's feature back, the offense began to focus on passing the ball more, which led to Sanders spending more time on the bench. Through the first six games, Sanders had a combined total of 57 carries for 270 yards and no touchdowns. In the team's week 7 matchup against the
Las Vegas Raiders, Sanders suffered a sprained ankle. This injury forced Sanders to miss three weeks of action. He returned in time for the team's week 11 showdown with the Saints. Sanders stepped back into a large role in the week 13 game against the
New York Jets, as he carried the ball a season high 24 times for 120 yards. In week 15 against the
Washington Football Team, Sanders recorded a season high 131 yards rushing on 18 carries. His hot streak came to an end during the Eagles' week 16 matchup against the
New York Giants, Sanders broke a bone in his hand, which forced him to miss the final two games of the regular season. In the 2021 season, Sanders recorded 137 carries for 754 rushing yards and 26 receptions for 158 yards across 12 games.
2022 In Week 4, Sanders ran for 134 yards and two touchdowns, helping the Eagles move to 4–0 on the season during a 29–21 win over the
Jacksonville Jaguars. In Week 12, Sanders rushed for a then-season high 143 yards and two touchdowns on 21 carries in a 40–34 win over the
Green Bay Packers and topped that two weeks later with 144 yards and two touchdowns on just 17 carries in a 48–22 win over the Giants. Sanders finished the 2022 season ranked among the league's top 10 in carries, rushing yards, and rushing touchdowns; his 1,269 yards were 5th most in the league, while his 259 carries and 11 touchdowns both ranked 8th. Sanders rushed 17 times for 90 yards in the Eagles' 38–7 win over the New York Giants in the
Divisional Round. In the
NFC Championship Game against the
San Francisco 49ers, Sanders rushed for two touchdowns in the 31–7 win. In
Super Bowl LVII, Sanders had seven carries for 16 yards in the Eagles 38–35 loss to the
Kansas City Chiefs.
Carolina Panthers On March 15, 2023, Sanders signed a four-year, $25.4 million contract with the
Carolina Panthers. In his debut against the
Atlanta Falcons, Sanders rushed 18 times for 72 yards and lost a fumble to Falcons linebacker
Lorenzo Carter late in the third quarter. The Panthers would go on to lose 24–10. Sanders's struggles continued in Week 2 against the Saints on
Monday Night Football, where he ran 14 times for a meager 43 yards in the 20–17 loss. In Week 3 against the Seahawks, Sanders recorded his first touchdown of the season, on a 1-yard run. He finished the game with 9 carries for 24 yards and the touchdown, and the Panthers lost 37–27. In Week 4 against the Vikings, Sanders rushed for a season-low of 19 yards on 13 carries as the Panthers dropped to 0–4. Against the
Detroit Lions in Week 5, Sanders recorded a season-low 7 carries for 32 yards. Sanders was ruled out the following week due to a shoulder injury. He would return in Week 8, where his workload drastically decreased. Against the
Houston Texans, Sanders carried the ball just 2 times for 0 yards. Sanders would then rush 6 times for 39 yards against the
Indianapolis Colts, before posting a career-worst performance with just 2 carries for −5 yards against the
Chicago Bears on
Thursday Night Football. In the following two weeks, Sanders saw his workload increase to 11 carries and then 15 carries against the Cowboys and
Tennessee Titans respectively. In Week 14 against the New Orleans Saints, Sanders turned in a season-high 74 rushing yards on 10 carries in the 28–6 loss. Sanders would go on to finish the season with career lows in carries, yards, and yards per carry. In the 2024 season, Sanders had 55 carries for 205 rushing yards and two rushing touchdowns to go with 24 receptions for 148 receiving yards and one receiving touchdown. He missed six games on the season with an ankle injury. The Panthers released Sanders on March 11, 2025.
Dallas Cowboys On March 14, 2025, Sanders signed a one-year contract with the
Dallas Cowboys. He was a backup behind
Javonte Williams and appeared in the first four games of the season. In Week 1, Sanders recorded a 49-yard run against his former team, the
Philadelphia Eagles, and was tackled at the 11-yard line, but had a costly red zone fumble on first down. After a couple of personal foul penalties by both teams, the contest was delayed for 65 minutes due to a lightning storm and Sanders didn't receive another carry in the 20-24 loss. In Week 4, he left the game in the second quarter against the
Green Bay Packers with an ankle injury. In Week 5, Sanders was declared inactive with ankle and knee injuries against the
New York Jets, while being replaced with rookie
Jaydon Blue. On October 10, he was placed on injured reserve with a season-ending left knee injury, which required surgery. Sanders finished the season with 20 carries for 117 yards, one rushing touchdown and 8 receptions for 30 yards. ==Career statistics==