Main •
"Weird Al" Yankovic as Milo Murphy, the title character of the series. He has a reputation for having extreme misfortune due to being a descendant of the creator of
Murphy's Law. Despite constant misfortune, he is optimistic and has a talent for overcoming his bad luck. He carries a backpack with him that seems to have what he needs for any given situation. It was given to him by his old babysitter, Veronica, who was the only one able to handle Murphy's Law. •
Sabrina Carpenter as Melissa Chase, Milo's best friend. He was once the lead singer of a
boy band called "The Lumberzacks".
Supporting The Murphys' house •
Diedrich Bader as Martin Murphy, Milo's father. Just like his son, he has extreme misfortune. He is a safety inspector, mostly due to the fact that when he's around, safety contingencies are pushed to the limit. •
Pamela Adlon as Brigette Murphy, Milo's mother who is an architect. •
Kate Micucci as Sara Murphy, Milo's older sister and fellow
Dr. Zone fan. •
Dee Bradley Baker as Diogee Ex Machina Murphy, Milo's dog. He regularly follows Milo, who keeps telling him to go home. His name is pronounced "d-o-g", and his middle name refers to the fact that he often appears out of nowhere, to help Milo out of seemingly hopeless situations. In general, his whole name is a play off of the phrase "deus ex machina" (with "god" as the translation of "deus"). •
Dan Povenmire as
Dr. Heinz Doofenshmirtz (a.k.a. "Professor Time"), a formerly-evil-scientist-turned-O.W.C.A. member. Doofenshmirtz becomes a supporting character in the second season, living in the Murphys' garden shed after his house is destroyed by Murphy's Law.
Jefferson County Middle School •
Chrissie Fit as Amanda Lopez, a student in Milo's class who is a perfectionist and serves as the love interest for Milo throughout the series. •
Vincent Martella as Bradley Nicholson, the main character of the eponymous show within a show, inspired by
the eponymous character from
Doctor Who. • Clement also voices Orton Mahlson, the creator and star of
Doctor Zone, whom Milo and his friends team up with to stop the Pistachions. His name is a parody of series writer
Martin Olson. •
Sophie Winkleman as Time Ape, Dr. Zone's sidekick. •
Rhys Darby as King Pistachion, a mutated pistachio that takes over Cavendish and Dakota's future with his army of Pistachions. • Scott D. Peterson as Scott, an "Undergrounder" who lives beneath Danville. • Vincent Martella as
Phineas Flynn, an upbeat young boy whom Milo and his friends team up with to stop the Pistachions. • David Errigo Jr. as
Ferb Fletcher, a boy of few words whom Milo and his friends team up with to stop the Pistachions. •
Ashley Tisdale as
Candace Flynn, Phineas' sister whom Milo and his friends team up with to stop the Pistachions. •
Maulik Pancholy as
Baljeet Tjinder, a friend of Phineas and Ferb's whom Milo and his friends team up with to stop the Pistachions. • Bobby Gaylor as
Buford van Stomm, a friend of Phineas and Ferb's whom Milo and his friends team up with to stop the Pistachions. • Alyson Stoner as
Isabella Garcia-Shapiro, a friend of Phineas and Ferb's whom Milo and his friends team up with to stop the Pistachions. •
Dan Povenmire as Colonel Niblet, head of a mysterious government agency. • Jeff "Swampy" Marsh as Lieutenant Tennant, a government lieutenant under Colonel Niblet. •
John Viener as the disembodied head of
Norm, Doof's formerly giant robot man. •
Olivia Olson as
Vanessa Doofenshmirtz, Doof's goth daughter from his failed marriage. •
Mitchel Musso as
Jeremy Johnson, Candace Flynn's boyfriend. • Maulik Pancholy as "Neal from the Comic Shop", Sara's love interest. ==Episodes==