The school was founded in 1908 by Katherine Delmar Burke and was named Miss Burke's School. The school's first location was at Steiner and Pacific Streets in
Pacific Heights. It then relocated to a house at 2310 Broderick Street. In 1918, the growing school moved to a new building designed by architect
Julia Morgan (a friend of Katherine Burke), located at 3065 Jackson Street. The school began acquiring property in Sea Cliff in 1929. At first, only the kindergarten and first grade were located there. The rest of the property was used as a sports venue for the upper classes. There was a large grass sports field, basketball courts, and 5 tennis courts. In 1949, grades 2 through 6 were moved there after the completion of new classrooms. The high school and grades 7 and 8 remained at the Jackson St. building until 1975, when Burke's high school closed and the building was acquired by
San Francisco University High School. While once known as a finishing school where a school play made local headlines, Burke's in 2009 was cited in the Irish American newspaper the Herald that concluded, "[Burke's] innovative work of preparing young girls to attend college is an important chapter in San Francisco’s history." ==Notable alumnae==