Tucker has been a huge fan of the
Playboy franchise since finding his friend Eugene's older brother's magazines when he was eight. Eugene and his girlfriend Cindi Whitehall are public speakers. They spend their time speaking to elementary school children about
abstinence and
sexually transmitted diseases. Eugene also relates what happened to his brother, Craig, who lost his mother and son in a fire and the grief led to him being institutionalized. Even though Eugene and Cindi preach about abstinence publicly, Cindi tells Eugene she wants to have sex with him for the first time. They plan to have sex at an after
prom party that Tucker has invited them to. At the party, Eugene is nervous and Tucker gives him several shots of hard alcohol. Eugene unwittingly heads through the basement door and falls down the steps, winding up in a
coma for four years. Tucker wakes Eugene from his coma by hitting him with a baseball bat, which unfortunately causes Eugene to
defecate constantly. They soon discover that Cindi has become the newest Playboy centerfold. Tucker devises a plan to go cross country from
South Carolina to the
Playboy Mansion and crash Playboy's annual Birthday bash in order to reunite Eugene with his old girlfriend. Tucker's girlfriend, Candace, also begins hunting him down after an incident where he stabbed her after she bit his genitals during an
epileptic seizure while performing
fellatio. They are immediately targeted by the local firefighters led by Candace's brother, Rick. The duo loses the tail and the firefighters reach out to other firefighters across the country, placing a bounty on Tucker's head. After accidentally burning down a hotel room, Eugene and Tucker find out that every firefighter in the country are hunting them down. In Chicago, Tucker runs low on funds due to his incompetent road trip planning and they meet up with their old friend, Phil, who has become a famous rapper with the MC name of Horsedick dot MPEG. They all hop on board his party bus and begin to trek across the country towards the Mansion. On the bus, Tucker is in a bedroom with Crystal, one of Horsedick's women. After bouncing up and down on the bed for Tucker's amusement, she accidentally flies out the open window. After learning that Cindi slept with Horsedick, Eugene slaps Horsedick and defecates on board, and Tucker and Eugene are thrown out of the bus in the desert and left to walk the rest of the way. Just as it seems like all hope is lost, a car pulls up with two Russian
lesbians, Katja and Vonka. The four make a deal where the boys do the driving to Los Angeles while the women are in the back seat having sex. They make it to the Mansion only to be stopped by bouncers at the door while the lesbians are let in. Candace and the firefighters arrive and are let in, giving Tucker and Eugene the perfect ploy to slip inside. While searching for Cindi, Eugene is suspected of being a stalker and is taken into a secure holding area, but not before being spotted by Cindi. Candace and the firefighters spot Tucker, who flees and hides. While hiding, Tucker meets
Hugh Hefner. Hugh and Tucker have a discussion about Tucker's love issues, and Hugh tells Tucker about the first woman he ever fell in love with. Hefner explains that "there is a bunny in every woman", and that if Tucker can only see the "bunny" in those women, that he's on to something. Hugh soon calls security upon learning that Tucker not only stabbed his girlfriend in the face with a fork, but the fact that firefighters want to kill him. Back in the holding area, Cindi comes in to see Eugene, who is not too keen on seeing her. Eugene accuses her of abandoning him, but Cindi tells Eugene that the money she made modeling and being a Playboy Bunny was sent to help pay for Eugene's hospital bills after his neglectful father wanted to permanently move him into hospice and let him die. She then pointed out that Tucker was receiving the mail, which sparked some ire in Eugene. Shortly after, both guys are thrown out of the Mansion. Tucker is handed to the firefighters to be beheaded and Tucker apologizes to Candace, begging for a second chance with her. She decides to give him another shot, which infuriates Rick and his fire crew. Eugene is handed over to Horsedick dot MPEG, who promised to "rip Eugene's face off". After Cindi reveals to everyone outside that Horsedick was born without genitals, his right-hand man realizes that he's never seen MPEG in action with a woman. At that moment, his crew pulls down his pants, showing nothing but two straws where his genitals should be. Horsedick leaves embarrassed and ashamed, and after Eugene and Cindi make up, Hefner lets everyone back in. Eugene and Tucker find themselves in the Mansion's kitchen, and Eugene tells Tucker that Cindi is waiting upstairs for him. They finally have sex, where Eugene "
overexerts" himself. During the credits, Eugene's doctor is attempting to resuscitate a coma with a baseball bat the same way Tucker did Eugene. The coma patient turned out to be Crystal, who woke up before the doctor struck her, promising to kill Tucker. ==Cast==