Mississippi Highway 161

MS 161 starts at US 61 and US 278, south of the town of Merigold. It passes through a small tract of farmland and intersects South Lane Road. The Taborian Hospital is also located on the route, outside the historic district. MS 161 also passes by the John F. Kennedy Memorial High School and crosses the waterway known as Mound Bayou near Lampard Street. and it crosses northwesterly over US 61 and US 278. Near Tarsi Road, the route turns north and enters Shelby as Broadway Street. MS 161 travels through the residential area of Shelby, and downtown Shelby near Fourth Avenue. The route intersects MS 32 at Second Avenue and travels northward through the town. The road exits the city limits past Blue Cain Road, and it turns eastward past the intersection. MS 161 ends at a three-way junction with US 61 and US 278 north of Shelby. Before US 61 was relocated to a four-lane divided highway, the two-lane road had stop signs and low speed limits that significantly slowed through traffic. ;Major intersections ==Clarksdale–Lyon==

MS 161 starts at an intersection with US 61, US 278, and MS 322 in Clarksdale. The route travels northeast, concurrent to MS 322, across several farms before reaching Sherard Road, where MS 322 continues westward to Sherard. Known as South State Street, MS 161 continues northeastward towards a commercial area of Clarksdale, and it crosses the Sunflower River. The road name changes to North State Street, and it intersects Desoto Avenue, which travels to downtown Clarksdale northbound and US 49 southbound. MS 161 turns east briefly at Lincoln Place, before continuing northeastward past Sycamore Street. The route travels along the edge of the city, and it soon intersects the western terminus of MS 6, which leads to US 278. The road enters Lyon north of the intersection, and it intersects Bobo and Fontaine Streets. MS 161 leaves the town north of Hopson Street and Roberson Road, and the road ends at a three-way junction with US 49 and US 61. US 61 was rerouted onto the new bypass around Clarksdale in August 2004, and MS 161 was designated on its old alignment. ;Major intersections ==Walls==

MS 161 starts at US 61 inside the city limits of Walls, and it travels along a two-lane road northeastward through a rural area. At Sullivan Road, the route enters the center of the town and begins to turn northward. MS 161 passes through the town, intersecting Second Street and Delta View Road. Past the center of the town, the road travels through more farmland and intersects MS 302 at a T-intersection. The route leaves the city limits of Walls, and it continues for before ending at US 61. In 1999, US 61 was rerouted out of Walls, and the old alignment became MS 161. ;Major intersections ==References==