state line. MS 27 begins in
Walthall County at the
Louisiana state line along the banks of the
Bogue Chitto River, with the road continuing south toward the town of
Franklinton as
Louisiana Highway 25 (LA 25). It heads northeast as a two-lane highway to pull away from the Bogue Chitto River as it travels through farmland for several miles, passing through the community of
Lexie, before entering the
Tylertown city limits. The highway enters town along Franklinton Street, passing by the city cemetery and through neighborhoods before entering downtown, where it has an intersection with
MS 48/
MS 198 (Beulah Avenue). MS 27 heads north from this intersection as Ball Avenue, which quickly becomes Tyler Avenue as it leaves downtown and re-enters neighborhoods. The highway has an intersection with
MS 583 (Tyler Avenue), becoming Union Road before having an intersection with
US 98 and leaving Tylertown. MS 27 travels north through mostly wooded areas for the next several miles, passing through the community of
Salem before entering
Lawrence County. MS 27 has an intersection with the western section of
MS 44 near the community of
Topeka before traveling through remote woodlands for several miles to enter the
Monticello city limits, with MS 27 completely bypassing the town along its western side, having an intersection with
MS 184 (W Broad Street), as well as an interchange with
US 84. The highway now leaves Monticello as it heads north through rural farmland and woodlands parallel to the
Pearl River for the next several miles, with it traveling through the communities of
Rosella (where it has an intersection with N.A. Sandifer Highway and crosses the
Fair River),
Wanilla (where it has an intersection with unsigned
MS 904/Smith Ferry Road), and
Oma before entering
Copiah County. MS 27 travels through woodlands as it passes through the communities of
Cowanville and
Rockport, where it has intersections with both
MS 478 and
MS 472, before passing through the town of
Georgetown, where it has an intersection with
MS 28. The highway curves northwest as it passes through the community of
Hopewell, where it pulls away from the Pearl River, before traveling along the northern edge of the
Crystal Springs city limits, where it temporarily widens to a four-lane divided highway, has an intersection with
MS 801 and an extremely short
concurrency (overlap) with
US 51, as well as an interchange with
I-55 (Exit 72). MS 27 narrows back down to two-lanes as it leaves the Crystal Springs area and travels northwest through remote woodlands for several miles to enter
Hinds County a few miles south of Dabney Crossroads. MS 27 travels west through a mix of farmland and wooded areas for several miles to the town of
Utica, which it bypasses along its eastern side via a concurrency with
MS 18. The highway leaves Utica and travels northwest through mostly wooded terrain for the next several miles to have an interchange with the
Natchez Trace Parkway before crossing the
Big Black River into
Warren County. MS 27 continues through woodlands to travel through the suburb of
Beechwood, where it passes by the Vicksburg campus of
Hinds Community College and widens to a four-lane undivided highway, before entering a business district and the
Vicksburg city limits at an intersection with
MS 822 (Old U.S. 80). MS 27 comes to an end shortly thereafter at a large interchange with
I-20/
US 80/
US 61 (Exit 5 A/B), with the road continuing north as northbound US 61. ==Major intersections==