MS 430 begins in the
Mississippi Delta region in
Leflore County in the city of
Greenwood at an intersection with
U.S. Route 82 (US 82)/
MS 7 just southeast of downtown. It heads southeast as a four-lane undivided highway through neighborhoods before leaving Greenwood and narrowing to two-lanes. The highway then crosses over
Pelucia Creek before entering
Carroll County. State maintenance of the highway temporarily ends at the county line as MS 430 travels southeast through farmland. It winds its way up some
Loess bluffs, where it climbs out of the Mississippi Delta as it gains some serious elevation. The highway travels through a mix of farmland and wooded areas for about to pass through
Blackhawk, where it has an intersection with
MS 17. State maintenance resumes at this intersection. MS 430 passes remote woodlands for about before re-entering farmland and entering the
Vaiden city limits, where it comes to an intersection and
runs concurrently with
MS 35. They head west to have an interchange with
Interstate 55 (I-55) at its exit 174 before MS 430 splits off along Mulberry Street and passes straight through downtown. MS 430 comes to an end shortly thereafter at an intersection with
US 51. ==Major intersections==