Eighty-six Missoula players have also played in Major League Baseball. They are: ;1999:
JD Closser,
Jorge de la Rosa,
Doug DeVore,
Lyle Overbay,
Duaner Sánchez,
Luis Terrero (1999–2000) ;2000:
Casey Daigle,
Jerry Gil,
Andy Green,
Phil Stockman,
José Valverde ;2001:
Scott Hairston ;2002:
Dustin Nippert,
Tony Peña,
Sergio Santos,
Miguel Montero (2002–2003) ;2003:
Emilio Bonifacio,
Carlos González, ;2004:
Wilkin Castillo,
Steven Jackson,
Esmerling Vásquez ;2005:
Pedro Ciriaco,
Rusty Ryal,
Greg Smith ;2006:
Héctor Ambriz,
Tony Barnette,
Gerardo Parra,
John Hester,
Jordan Norberto,
Daniel Stange,
Clay Zavada ;2007:
Bryan Augenstein,
Tommy Layne,
Evan Scribner,
Rey Navarro (2007–2008) ;2008:
Jake Elmore,
Daniel Schlereth,
Bryan Shaw ;2009:
Chase Anderson,
Mike Belfiore,
Charles Brewer,
Keon Broxton,
Eury De La Rosa,
Paul Goldschmidt,
Bradin Hagens,
Ender Inciarte,
Chris Owings,
Patrick Schuster (2009–2010),
Enrique Burgos (2009, 2011) ;2010:
Adam Eaton,
David Holmberg,
Stephen Cardullo (2010–2011) ;2011:
Archie Bradley,
Ryan Court,
Keith Hessler,
DJ Johnson ;2012:
Socrates Brito,
Jake Lamb,
Michael Perez,
Andrew Velazquez ;2013:
Silvino Bracho,
Steve Hathaway,
Daniel Palka,
Brad Keller (2013–2014),
Justin Williams (2013–2014) ;2014:
Sergio Alcántara,
Kevin Cron,
Touki Toussaint,
Gabriel Moya (2014–2015),
Yefry Ramirez (2014–2015),
José Herrera (2014, 2016) ;2015:
Isan Díaz,
Marcus Wilson ;2016:
Jazz Chisholm Jr.,
Jhoan Durán,
Luís Madero (2016–2017),
Luis Castillo (2016, 2018) ;2017:
José Caballero,
Elvis Luciano ;2018:
Buddy Kennedy,
Cristofer Ogando,
Geraldo Perdomo,
Alek Thomas ;2019:
Dominic Canzone,
Justin Martínez,
Liover Peguero ==Roster==