US 40, along with I-70, US 24, and US 169, enters Kansas City via the
Intercity Viaduct. US 169 exits the freeway north to the
Buck O'Neil Bridge and I-35 joins with the remaining three routes. At the interchange with I-29 and US 71, I-70, US 24, and US 40 turn south while I-35 turns north. At I-670, I-70, US 24, and US 40 turn east while US 71 continues south toward
I-49. In
East Side, US 40 leaves I-70 before meeting I-435/US 24. Shortly after I-435, US 40 runs along or parallels the Kansas City–Independence line. Between I-470 and Blue Springs, the two roadways splits. At Grain Valley, US 40 rejoins I-70. For , US 40 runs along I-70 through rural areas, meeting US 65 at Marshall Junction as well as multiple state highways in different locations. US 40 eventually leaves the freeway to serve downtown Boonville, running concurrently with
I-70 Bus. and Route 5 in the process. As the road approaches downtown, I-70 Bus. turns southeast while US 40 and Route 5 turns north, both running along Route 87. After leaving downtown and crossing above the
Missouri River, Route 87 and then Route 5 leaves northward from US 40. US 40 parallels the Missouri River before reaching Rocheport; the route then parallels I-70. US 40 reenters the freeway just after
Midway. I-70/US 40 runs north of
downtown Columbia. The freeway serves US 63 via a connector road, located east of the US 63 freeway. US 40 continues to run along I-70 through rural areas between Columbia and Wentzville; the freeway, at one point, meets US 54 in Kingdom City. In Wentzville, at the Greater St. Louis area, US 40 leaves I-70 to enter I-64/US 61. US 40, along with I-64 and US 61, then crosses the Missouri River again, this time via the
Daniel Boone Bridge. After crossing the river, the freeway serves the
Spirit of St. Louis Airport in Chesterfield. At the Frontenac–Ladue line, US 61 leaves the freeway to enter south along US 67 (Lindbergh Boulevard). Next to the I-170 interchange in Richmond Heights, drivers can get on the
Brentwood I-64 station on the
Blue Line. Just after entering St. Louis proper, I-64/US 40 pares through the southern part of
Forest Park. The freeway then becomes a double-decker twice: from Vandeventer Avenue to Compton Avenue and from 14th Street (near the
Gateway Transportation Center) to an interchange with I-44/I-55. I-55 merges with I-64/US 40 near
Gateway Arch. The freeway then crosses above the
Mississippi River via the
Poplar Street Bridge to enter Illinois. ==History==