Route 19 begins at
U.S. Route 61 in New London. It then travels mainly south, forming an 8-mile concurrency with
U.S. Route 54, 3 miles west of Farber. The highway intersects
Interstate 70 near
New Florence. It crosses the
Missouri River on the
Christopher S. Bond Bridge at
Hermann. There is a concurrency with
Missouri Route 100 through Hermann. It then forms a brief 1 mile concurrency with
U.S. Route 50 at Drake. Through
Owensville there is a concurrency with
Route 28. The highway intersects
Interstate 44 at
Cuba. South of Cuba, the highway is designated as a scenic highway. It forms a concurrency with
Route 8 through
Steelville. It passes through the
Ozark National Scenic Riverways and portions of the
Mark Twain National Forest. The highway overlaps
U.S. Route 60 in Winona and
U.S. Route 160 in Alton. The highway terminates at
U.S. Route 63 in
Thayer. ==History==