Route 76 begins at Willow Springs. Within a couple of miles, the highways enters the
Mark Twain National Forest, which it leaves after . At the
Douglas County line it begins a
concurrency with
Route 181. North of
Vanzant is an intersection with
Route 95, and further west is the northern junction with
Route 5. On the west side of Ava, Route 76/Route 5 has an intersection with
Route 14, and south of Ava, Route 76 will turn west off Route 5. At Brownbranch, the highway enters another part of the Mark Twain National Forest, and at Bradleyville, it has a short concurrency with
Route 125. At Kissee Mills, the road turns west with
U.S. Route 160 and the two are united to Forsyth. At Forsyth, Route 76 leaves US 160 and crosses
Bull Shoals Lake. At Branson, the road crosses
Lake Taneycomo and meets
U.S. Route 65. Route 76 runs concurrent with US 65 for before exiting onto the Ozark Mountain Highroad Freeway. While on the freeway, Route 76 has an interchange with
Route 248. At the west end of the highroad, Route 76 returns to its original route at an incomplete interchange, connecting with
Route 376. On the west side of Branson, a concurrency with
Route 265 begins; at Branson West, a concurrency with
Route 13 begins. At Reeds Spring, Route 76 turns west towards Cape Fair. At Cape Fair is the southern terminus of
Route 173. At the
Barry County line, Route 76 enters the Mark Twain National Forest for a third time. Eight miles () into the forest is a short, one-mile (1.6 km) concurrency with
Route 39. At the west limits of the national forest, Route 76 unites with
Route 86; they are concurrent for . At Cassville is a short concurrency with
Route 112 and an intersection with
Route 37. The road becomes less winding and hilly in this area. At Wheaton, Route 86 turns north. Route 76 continues west through
McDonald County. At Anderson, Route 76 has an interchange with
Interstate 49/
U.S. Route 71, and just west is a two-mile (3 km) concurrency with
Route 59. Seven miles west of Anderson, the highway joins
Route 43, turning north with that highway three miles. At the northwest junction, Route 76 turns west for one mile (1.6 km) and enters Tiff City. The western limit of Tiff City is the Oklahoma state line, where Route 76 becomes a county road on the county line of
Ottawa County and
Delaware County, Oklahoma. ==History==