Main cast •
Jerry O'Connell as
Herman Munster, a man made from parts of other people. Unlike Herman in the original series, Herman looks human except for some very obvious scars. He is very intelligent but has a sensitive heart. He loves his family, and to a lesser extent his father-in-law. His heart, the last remaining part from his original body, is dying because he "loves too hard". •
Portia de Rossi as
Lily Munster (née Dracula) the elegant matriarch of the Munster family and a vampire. Unlike her father, Lily tries not to attack or manipulate humans. She loves her family very much and only wants them safe. •
Charity Wakefield as
Marilyn Munster, Lily's niece, is a normal human and has no monster-like attributes. She is considered the oddball of the family because she looks and acts normal. Her mother tried to eat her, but Grandpa talked her out of it. •
Mason Cook as
Eddie Munster, an apparently normal adolescent boy who does not initially know that he is a werewolf. When Herman and Lily are forced to break this news to him, they obtain for him a pet dragon to watch over him during his transformations. •
Eddie Izzard as
Grandpa, Lily's father, also a vampire. He likes to act like he is the head of the family. He enjoys making wisecracks at Herman's expense. This version of Grandpa is much darker than the character in the original series, exhibiting predatory behavior and a fondness for murder and mind control.
Guest cast •
Cheyenne Jackson as Scoutmaster Steve, a widower and leader of Eddie's scout troop who becomes smitten with Lily. Grandpa plots to kill him so he can feed off his blood and replace Herman's heart; despite Herman's clear protests. Grandpa gets his way when Steve dies in an accident. •
Beth Grant as Marianne Marie Beetle, the
paraplegic busybody neighbor who takes a very keen interest in the strange new family next door. This character previously appeared in episodes of
Wonderfalls and
Pushing Daisies. •
Guy Perry as Werewolf •
John Kassir as Tim, Marie's husband ==Production==