Mansour joined Zamalek in 1992, then he served as a board member from 1996 until 2001, when he became vice-president to
Kamal Darwish, before winning the club's presidential election against the latter in April 2005. which was later reduced to one year. In 2009, he lost the elections against
Mamdouh Abbas, before defeating Kamal Darwish in 2014. On 4 October 2020, the board of directors of the
Egyptian Olympic Committee decided to suspend Mortada Mansour from practicing any sporting activity in Egypt for four years, based on complaints submitted by the president of
Al-Ahly,
Mahmoud El Khatib, and many others. On 22 November 2021, Mansour and his board of directors officially returned back to Zamalek SC management, following the departure of the normalization committee until the club's next elections. On 12 February 2022, he returned to his position at Zamalek for the third time, by defeating Major general Ahmad Suleiman in the elections held by the club through the general assembly. On 25 February 2023, Mansour turned himself in to Egyptian authorities to serve a one-month prison sentence at
Wadi el-Natrun, over a defamation case against Al-Ahly president Mahmoud El Khatib. On 30 March, he resumed his duties at Zamalek after serving his prison sentence. On 16 April, the Court of administrative justice ruled that Minister of Youth and Sports,
Ashraf Sobhy, had to remove Mansour from his position as Zamalek president. On 3 August, he announced his departure from Zamalek four months after the court's decision, ahead of club's elections on 31 October. ==Personal life==