After graduating in medicine, Mosley elected not to pursue a career as a doctor, but instead joined a trainee assistant producer scheme at the
BBC in 1985. His career in front of the camera began in 2007, when he pitched a series for BBC television titled
Medical Mavericks and, unable to find a suitable host, offered to present it himself. In 2011, Mosley made a series titled
The Brain: A Secret History on the history of psychology and
neuroscience. During the series, while describing the methods that are being employed to identify the anomalies in brain structure associated with
psychopathy, his personal test results revealed he himself had these candidate brain characteristics. Mosley presented a two-part documentary,
Frontline Medicine, in 2011, with episodes titled "Survival" and "Rebuilding Lives". These programmes described the recent medical advancements that allowed for improved treatment of military personnel injured in
battle in Afghanistan, and examined how these new techniques were being used in emergency medicine in civilian casualties in the United States and Great Britain. Mosley's documentary
The Truth About Exercise, first broadcast in 2012, highlighted how different patterns of exercise might help achieve health benefits, the danger of sitting for prolonged periods and revealed how certain
genotypes are unable to gain significant improvements in aerobic fitness (
VO2 max) by following endurance exercise programmes. His own genetic type can gain many of the benefits of
exercise, primarily improved
insulin response, through short,
high-intensity training sessions as suggested by the research of James Timmons. In January 2013, Mosley presented
The Genius of Invention. In the documentary named
The Truth About Personality, which first aired on 10 July 2013, Mosley explored what science can tell people about optimism and pessimism and whether people can change their outlook. '' In 2016 he presented the
BBC Four documentary ''Inside Porton Down: Britain's Secret Weapons Research Facility''. Mosley, along with a group of medical specialists, presented a BBC Two documentary series titled
The Diagnostic Detectives which aired in 2020. In the series, each programme is centred around the group of doctors who choose to tackle a patient's problem. In 2021, Mosley presented a three-part series,
Lose a Stone in 21 Days, for
Channel 4. On the programme Mosley suggested that people could lose a
stone () in 21 days by
calorie restriction to only 800 calories a day. This advice was considered dangerous by some medical experts and the programme received criticism on social media platforms.
Beat, a UK charity supporting those affected by
eating disorders, wrote the following day that "the programme caused enough stress and anxiety to our beneficiaries that we extended our Helpline hours to support anyone affected and received 51% more contact during that time". Mosley presented the series
Just One Thing on
BBC Radio 4, in which each episode explored a single action a person could take to improve their health. Suggestions covered a wide range including reading poetry out loud, taking hot baths in the evening, playing a musical instrument,
Nordic walking, and cooking tomatoes to increase their health benefits. , 102 episodes had been broadcast with three more, sharing the title "Exercise Clever", scheduled for 13, 20 and 27 June 2024. These were later pulled. An interview he recorded at the
Hay Festival less than a fortnight before his death was broadcast as part of the series and as a tribute to him. In it, he was praised as "one of the most important broadcasters of recent decades" and he confessed that he found it challenging to practise many of the health tips he had advocated on his programmes and that he had found the results of a
personality test confronting. == Intermittent fasting and low-carbohydrate diet advocacy ==