Texas Legends (2022–2023) On September 21, 2022, Gueye signed with the
Dallas Mavericks of the
National Basketball Association (NBA). On October 23, 2022, Gueye was listed on the training camp roster of the Mavericks'
NBA G League affiliate team,
Texas Legends. On November 3, 2022, Gueye was named to the opening night roster for the
Texas Legends. He averaged 8.6 points, 5.1 rebounds, 1.5 assists and 1.9 blocks per game in 29 games played. and on July 21, 2023, the Legends traded his G League rights to
Raptors 905. On August 1, he signed a contract with the Raptors, but was waived on October 20. Ten days later, he joined
Raptors 905. On December 1, he sustained a neck injury during the game against the Maine Celtics. Gueye was the leading candidate for a
two-way contract with Toronto at the time but the injury ruled him out; the team instead signed
Jontay Porter. On February 10, 2024, Gueye signed a 10-day contract with Toronto and two days later, he made his NBA debut on February 12 against the
San Antonio Spurs, recording two points, three rebounds and two blocks in six minutes. On February 20, he returned to Raptors 905 and on March 4, he signed a two-way contract with Toronto. Gueye appeared in 11 games for Toronto and averaged 2.4 points and 2.1 rebounds per game. On June 25, 2024, the Raptors waived Gueye.
Capital City Go-Go (2024–2025) After joining the
Charlotte Hornets for the
2024 NBA Summer League, Gueye signed with the
Washington Wizards on October 13, 2024. However, he was waived six days later and on October 28, he joined the
Capital City Go-Go. On September 10, 2025, Gueye signed an
Exhibit 10 contract with the
Chicago Bulls. He was waived prior to the start of the regular season on October 13.
Windy City Bulls (2025–2026) Mouhamadou played for the
Windy City Bulls for the
2025–26 NBA G League season, averaging 15.9 points, 7.4 rebounds, and 2.1 assists.
Chicago Bulls (2026–present) On April 9, 2026, Gueye signed a contract with the
Chicago Bulls for the remainder of the season. ==Career statistics==