Mpanga-Kipengere Game Reserve is a protected area in Njombe Region of the Southern Highlands, Tanzania. It covers an area of 1,574 km2 (608 sq mi) and ranges in elevation from 1,800 to 2,289 m. In addition to the preservation of wildlife the reserve is an important catchment for the headwaters of several rivers that feed into the Great Ruaha River and provide water for the Usangu wetlands.