Mucin 2

This gene encodes a member of the gel-forming mucin protein family. The protein encoded by this gene, also called mucin 2, is secreted onto mucosal surfaces. ==Genetics==

The mucin 2 protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. == Goblet cell mediated MUC2 secretion ==

Newly synthesized MUC2 proteins are densly packed in mucus granules and transported to the plasma membranes within goblet cells. Those mucus granules fuse with the plasma membrane and MUC2 is being released into the gut lumen. Due to its physical properties, MUC2 expands and disperses upon release, becoming a part of the existing mucus barrier. == References ==