Muhammad accompanied his brother Abdulaziz on the latter's raid from November 1901 to January 1902, which resulted in Abdulaziz retaking the
Masmak Castle and regaining control over Riyadh. Muhammad and his cousin
Saud Al Kabeer bin Abdulaziz led the forces which helped Abdulaziz in the
battle of Kanzan in 1915. In that battle the
Al Ajman tribe wounded Abdulaziz and killed Muhammad's younger half-brother
Saad bin Abdul Rahman. The Al Ajman then surrounded Abdulaziz's forces for almost six months before Abdulaziz managed to escape from them with the assistance of Muhammad and Saud Al Kabeer. In 1917 Muhammad went to
Hajj being the first Al Saud member who made the pilgrimage after the establishment of the
Kingdom of Hejaz in 1916.{{cite journal|author=Joshua Teitelbaum|title=Hashemites, Egyptians and Saudis: the tripartite struggle for the pilgrimage in the shadow of Ottoman defeat|journal=
Middle Eastern Studies After Abdulaziz took control over most of Arabia and proclaimed himself king, Muhammad was appointed governor of
Mecca.{{cite book Prince Muhammad and other senior family members met with King Abdulaziz upon the latter's request in late December 1934 to reaffirm their allegiance to Crown Prince Saud. However, Muhammad and his brothers Abdullah and Ahmed told the king that their allegiance to him was still active, but they did not renew their allegiance to the crown prince. Then they sent a letter to King Abdulaziz explaining the reasons for their views about Crown Prince Saud. ==Personal life and death==