In 2012, Isaac became the director of Christ at the Checkpoint (CATC), a conference which seeks to encourage and organize opposition to the
Israeli occupation of Palestine among Christians from other countries. According to Isaac, CATC has contributed to more awareness of Palestinian viewpoints among
Evangelical Christians. Palestinian pastor
Mitri Raheb mentored Isaac and encouraged him to become a pastor. In 2016, Isaac became an ordained minister in the
Evangelical Lutheran Church in Jordan and the Holy Land (ELCJHL). As of 2019, Isaac estimated that Christmas Lutheran Church had 160 local members with thousands more living abroad. Many
Palestinian Christians have left the West Bank due to the Israeli occupation and high rates of unemployment. He co-wrote an op-ed in
Haaretz predicting that the plan would not achieve peace between Israelis and Palestinians but would instead harm the rights of Palestinians, especially Palestinian Christians. Additionally, he called it "a mortal blow to a dynamic Christian presence in the birthplace of Jesus." Isaac appeared in
'Til Kingdom Come (2020), an Israeli documentary about American Christian support for Israel. In the film he explains his view to pastor William Bingham that
Christian Zionism contributes to the oppression of Palestinians. After their conversation, Bingham calls Isaac an
anti-semite and says that Palestinians do not exist.
Gaza war In November 2023, Isaac brought a letter from several Bethlehem churches to US President
Joseph Biden urging him to end the
Gaza war. During
advent season that year, Isaac compared the story of
Jesus's birth to the situation in Palestine. On Christmas Eve, Isaac preached a sermon entitled "Christ in the Rubble: A Liturgy of Lament" in which he stated: "We, the Palestinians, will recover, as we always have... But for those who are complicit, I feel sorry for you. Will you ever recover from this?... we will not accept your apology after the
genocide." Video of his sermon and photos of the nativity scene went
viral on social media. According to Isaac, churches in other countries have sent him photos of their similar nativity scenes. Isaac has given speeches in various venues across the world, including the
Riverside Church in New York City,
St. Mark's Episcopal Church in Washington, D.C., and the Global Anti-Apartheid Conference for Palestine in Johannesburg. Following Isaac's speech at a pro-Palestine protest in
London that featured
Jeremy Corbyn, the Archbishop of Canterbury
Justin Welby cancelled their February 2024 meeting. Welby reportedly decided against meeting with Isaac because he feared offending the Jewish community. After Isaac and others publicly criticized Welby's actions
, Welby apologized and rescheduled their meeting. Isaac has criticized Israel's treatment of Palestinian Christians. In an April 2024 interview with conservative commentator
Tucker Carlson, Isaac accused Israel of committing
genocide in Gaza. The interview, which garnered mixed reactions from American conservatives, In December 2024, Isaac expressed frustration at the lack of progress made towards ending the war but noted that Israel's conduct during the war has led to decreasing support for Israel among Christians in other countries. Other churches including
St. Mark's Episcopal Church in Washington, D.C., and
All Saints Episcopal Church in Pasadena, California, have created similar nativity scenes inspired by the one at Isaac's church. Isaac delivered a sermon entitled: "Christ Is Still in the Rubble", stating: "'Never again’ has become ‘yet again’ — yet again to supremacy, yet again to racism and yet again to genocide." == Books ==