Samaira was born circa 1979 to Azhar Nazir, Sr. and Irshad Begum. Described as "the brightest of the family", she studied travel and tourism at
Thames Valley University, taking a directorship role at her brother's recruitment consultancy business following graduation. The Nazir family also owned the Rana Brothers Grocery store in
Southall Broadway where Samaira's brother, Azhar Nazir, worked and first met Salman Mohammed. Mohammed had arrived in the United Kingdom from
Afghanistan as an illegal immigrant in 2000 and had approached Nazir for help finding accommodation and work. Samaira met Mohammed through his involvement with her brother; their relationship developed over several years, but knowing that Samaira's family would not approve, they kept the relationship a secret until, ultimately, they fell in love and decided they wanted to marry. Additionally, he'd already contracted a
marriage of convenience to support his immigration status and Samaira's brother claimed he was dishonest and involved in illegal activities. Regardless, in March 2005, Samaira told her family that she was engaged to Mohammed; Mohammed claimed that Samaira's father had threatened him with a knife and that her brother had threatened to kill them both as a result of their engagement. ==Murder and investigation==