Born in
Chicago, Landers began her career as a concert singer before moving to
New York City to pursue acting. She initially found it difficult to find parts because of her weight (Landers was and weighed 200 pounds), but found her niche in comedy. In 1951, Landers appeared on the variety series
The Frank Sinatra Show. Her performance on the series caught the attention of
Jack Benny who invited her to perform with him at the
London Palladium. Landers later appeared with Benny in two episodes of
The Jack Benny Program in 1956 and 1958. She also performed on ''
Where's Raymond?, starring Ray Bolger; The Jimmy Durante Show; The Andy Griffith Show; and Cavalcade of Stars, hosted by Jackie Gleason. In 1952, Landers made her feature film debut in the comedy Bela Lugosi Meets a Brooklyn Gorilla, starring Duke Mitchell and Sammy Petrillo. That same year, she won a regular role on the sitcom Life with Luigi''. The series was canceled in 1953. In 1957, she was signed by producer
Jules White to co-star in a new series of short-subject comedies for
Columbia Pictures. This was a bold move, because most studios had discontinued shorts and White was the only man still making them. The pilot film for the new "Girlie Whirls" series,
Tricky Chicks, cast Muriel Landers and
Bek Nelson as chubby and slender showgirls. The series was abandoned after the one film. In 1958, she appeared in the
Three Stooges short
Sweet and Hot. In the film, she portrayed
Joe Besser's sister "Tiny", who is a singer with stage fright. She performs the song "The Heat Is On" (in footage taken from
Tricky Chicks). The next year, Landers had a supporting role in the romantic comedy
Pillow Talk, starring
Rock Hudson and
Doris Day. Landers continued to play funny fat girls in television shows. She appeared in the May 18, 1959, season six episode of
The Danny Thomas Show (starring
Danny Thomas) entitled "The Practical Joke" as a chubby maid who wants to make it in show business. In 1960 and 1961, she appeared in two episodes of
Pete and Gladys as Gladys' cousin Violet. She also had a recurring role as "Mildred Cosgrove" on
The Joey Bishop Show. In addition to her comedic roles, Landers also guest starred on several dramas and
Westerns including
The Gene Autry Show,
Peter Gunn,
The Dick Powell Show, and
The Eleventh Hour. In 1962, Landers made a memorable appearance in
The Twilight Zone episode "
A Piano in the House", playing Marge Moore, an overweight woman who is forced to reveal her inner sadness about feeling unloved and unwanted because of her girth. In 1963, she and actor
Stanley Adams released the comedy record
Marriage Is for Dinosaurs through
Bigtop Records. The next year, she had a role in the comedy film
The Disorderly Orderly. For the remainder of the decade, Landers continued with guest starring roles on
The Beverly Hillbillies,
My Three Sons, and ''
Hogan's Heroes. In 1967, she portrayed the role of Mrs. Blossom in Doctor Dolittle''. It would be her last film role. In December 1968, she joined the cast of ''
Rowan and Martin's Laugh-In'' and appeared in a few episodes. One of Landers' last roles was as Mommy Hoo Doo in an episode of the children's television series
Lidsville, in 1971. Her final onscreen role was in the 1974 television film
Remember When. ==Death==