Main • Elisa Del Genio (season 1; guest season 2),
Margherita Mazzucco (seasons 1–3),
Alba Rohrwacher (season 4;
cameo season 3; narration seasons 1–4), and Elisabetta De Palo (featured season 4; guest season 1) as Elena "Lenù" Greco •
Ludovica Nasti (season 1; guest season 2),
Gaia Girace (seasons 1–3; special appearance season 4), and (season 4) as Raffaella "Lila" Cerullo • Anna Rita Vitolo as Immacolata Greco • Luca Gallone as Vittorio Greco • Imma Villa as Manuela Solara (seasons 1–3) • Antonio Milo as Silvio Solara (season 1; recurring season 2) • Valentina Acca as Nunzia Cerullo (seasons 1–2, 4) • Antonio Buonanno as Fernando Cerullo (seasons 1–3; recurring season 4) • Dora Romano as Miss Oliviero (seasons 1–2) • Alessio Gallo (seasons 1–3) and
Edoardo Pesce (season 4) as Michele Solara • Nunzia Schiano as Nella Incardo (seasons 1–2) • Giovanni Amura as Stefano Carracci (seasons 2–3; recurring season 1) • Gennaro De Stefano (season 2; recurring season 1) and
Salvatore Striano (season 4) as Rino Cerullo • Francesco Serpico (seasons 2–3; recurring season 1) and
Fabrizio Gifuni (season 4) as Giovanni "Nino" Sarratore • Federica Sollazzo as Pinuccia Carracci (season 2; recurring season 1) • Clotilde Sabatino as Professor Galiani (seasons 2–3) • Ulrike Migliaresi as Ada Cappuccio (season 2; recurring season 1) • Christian Giroso as Antonio Cappuccio (season 2; recurring season 1) •
Eduardo Scarpetta as Pasquale Peluso • Giovanni Buselli (seasons 2–3; recurring season 1) and Pio Stellaccio (season 4) as Enzo Scanno • Giovanni Cannata as Armando Galiani (seasons 2–3) •
Francesco Russo as Bruno Soccavo (seasons 2–3) • Bruno Orlando (seasons 2–3) and Stefano Dionisi (season 4) as Franco Mari • Daria Deflorian as Adele Airota (seasons 2–4) • Matteo Cecchi (seasons 2–3) and Pier Giorgio Bellocchio (season 4) as Pietro Airota • Giulia Mazzarino (season 3; recurring season 2) and Sonia Bergamasco (season 4) as Maria Rosa Airota • Gabriele Vacis as Guido Airota (season 3; recurring seasons 2, 4) • Maria Vittoria Dallasta as Silvia (season 3) • Riccardo Palmieri as Gino (season 3; recurring seasons 1–2) • Giorgia Gargano as Nadia Galiani (season 3; recurring season 2, featured season 4) • Fabrizio Cottone (season 3; recurring seasons 1–2) and Renato De Simone (season 4) as Alfonso Carracci • Rosaria Langellotto as Gigliola Spagnuolo (season 3; recurring seasons 1–2) • Pina Di Gennaro as Melina Cappuccio (season 3; recurring seasons 1–2, 4) • Francesca Pezzella as Carmela "Carmen" Peluso (season 3; recurring seasons 1–2) • Sofia Luchetti (season 3), Vittoria Cozza (season 4) and Ludovica Rita Di Meglio (season 4) as Adele "Dede" Airota • Salvatore Tortora as Gennaro "Gennarino" Carracci (season 3) • Elvis Esposito (season 3; recurring seasons 1–2) and
Lino Musella (season 4) as Marcello Solara • Francesca Montuori (season 3) and Claudia Tranchese (season 4) as Elisa Greco • Chiara Celotto as Eleonora Sarratore (season 3) • Sophia Protino (season 3), Fatima Credendino (season 4) and Adriana Trotta (season 4) as Elsa Airota
Featured The following actors are credited in the opening titles of a single episode of the series: • Antonio Pennarella as Don Achille Carracci (season 1) • Edu Rejón as Juan (season 3) • Giulia Pica as a doctor (season 3) • Claudio Lardo as Giuntini (season 3) • Mirko Setaro as Lila's cardiologist (season 3) • Vittorio Ciorcalo as Lila's neurologist (season 3) • Giovanni Toscano as Mario's friend (season 3) • Eugenio Di Fraia as Mario Gioia (season 3) • Rebecca Fanucchi as Clelia (season 3) • Iacopo Ricciotti as Maria Rosa's boyfriend (season 3) ==Episodes==