After graduating, Myint Htwe worked in the Ministry of Health for 17 years. In 1994, he was appointed a Regional Adviser for the
WHO South-East Asia Regional Office (WHO SEARO), where he served in various positions until his retirement in 2011. As Director of Programme Management at WHO SEARO he was instrumental in supporting Member Countries in their health development efforts. As
public health physician, he was a chairperson of the Preventive and Social Medicine Society of the
Myanmar Medical Association. In 2014, during the government of former General
Thein Sein, he was a member of the committee that drafted two of the four bills designed to regulate religious conversion and population-control measures in Myanmar. On 22 March 2016, he was nominated as Minister for Health and Sports in President
Htin Kyaw's Cabinet, which was Myanmar's first democratically elected civilian government since 1962. On 24 March 2016, the
Assembly of the Union confirmed his nomination. In the aftermath of the military-led
2021 Myanmar coup d'état, the
Myanmar Armed Forces appointed
Thet Khaing Win as Myint Htwe's successor on 1 February 2021. ==Personal life and death==