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Myosmine

Myosmine is an alkaloid with the formula NC5H4−C4H6N. It is structurally and biosynthetically related to nicotine, being also found in tobacco and several other plants. Chemically, it is closely related to nicotine. It inhibits aromatase sevenfold more potently than nicotine. It also releases dopamine in adult but not adolescent rats.

Chemical synthesis
Myosmin can be prepared in the laboratory from 3-lithiopyridine via condensation with cyclobutanone to give the pyridyl-cyclobutanol. Reaction of the latter tertiary alcohol with hydrazoic acid under conditions for the Schmidt reaction gives myosmine. Reduction of the imine group in myosmin with sodium cyanoborohydride affords nornicotine. == See also ==
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