NMYC interactor (NMI) interacts with
NMYC and
CMYC (two members of the oncogene
Myc family), and other transcription factors containing a
Zip,
HLH, or HLH-Zip motif. The NMI protein also interacts with all
STATs except
STAT2 and augments STAT-mediated transcription in response to cytokines
IL-2 and
IFN-gamma. The NMI
mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-
myeloid leukemias. ==Interactions==