In the aftermath of her NCAA career in 2001, she taught an Introduction to Ice Hockey class in the kinesiology department during the 2001–02 academic year at the University of Minnesota. In 2003, she became head coach of the Northfield Mount Hermon School girls’ hockey team in Gill, Massachusetts. In 2007, Muzerall coached at the Digit Murphy Hockey Camp at Brown University. Previously, she was a camp director at the Florida Hockey Camp in Orlando, Florida. Starting in 2008, Muzerall has coached at the Hill Hockey Clinic in Newburyport, Massachusetts. She instructed players on skating fundamentals along with off-ice training. On October 27, 2011, it was announced that she became an assistant coach for the Minnesota Golden Gophers women's ice hockey team. She would capture Frozen Four titles in 2012, 2013, 2015 and 2016. Muzerall was named an assistant coach of Canada's National Women's Development Team for the 2016–17 season. She has served as a coach in prior years at selection camps for Canada's National Women's Development Team and Canada's National Women's Under-18 Team. Muzerall was named as the head coach of the Ohio State women's hockey team prior to the 2016–17 season. She helped guide the team to the school's first NCAA tournament and Frozen Four appearance in 2018. On March 8, 2020, the Buckeyes won the
WCHA championship for the first time in the program's history. On March 20, 2022, the Buckeyes won the NCAA Women's Hockey National Championship for the first time in the program's history. Muzerall won the USCHO Coach of the Year award in 2022. In the
2022–23 season, Muzerall coached the Buckeyes to their second straight #1 overall seed in the
2023 NCAA Division I women's ice hockey tournament. The Buckeyes lost 1–0 to Wisconsin in the championship game. During the
2023–24 season, she led the Buckeyes to their second NCAA championship in program history. On May 20, 2024, Muzerall signed a five-year contract extension with Ohio State through the 2028–29 season. ==Head coaching record==