Jilani served as Nazim of District Khairpur She served as chair of the National Commission for Human Development and general secretary of the Women's Parliamentary Caucus between 2008 and 2013. She also headed the National Commission for Human Development. She was re-elected to the National Assembly as a candidate of PPP on a seat reserved for women from Sindh in the
2013 Pakistani general election for the second time. She was re-elected to the National Assembly as a candidate of PPP from
NA-208 (Khairpur-I) in the
2018 Pakistani general election. She received 107,978 votes and defeated
Syed Ghous Ali Shah, a candidate of the
Grand Democratic Alliance (GDA). She was re-elected to the National Assembly as a candidate of PPP from
NA-202 Khairpur-I in the
2024 Pakistani general election. She received 152,511 votes and defeated Syed Ghous Ali Shah, a candidate of the GDA. ==books==