Sonenberg's primary research has been on the translational control of
protein synthesis. Sonenberg also discovered the
Internal ribosome entry site (IRES) mode of translation, the cap-independent initiation of translation, which is critical for some mRNA involved in stress, cell cycling and apoptosis. Currently, he has expanded his research into topics such as the roles of translation in neurobiology and synaptic plasticity. Presently, his lab works on translational control in cancer, oncolytic viruses as anti-cancer drugs, microRNA control of translation, and translational control of plasticity, learning and memory. He received the
Gairdner Foundation International Award in 2008 for his contributions to medical science. He was appointed an Officer of the
Order of Canada in 2010. In 2014, Sonenberg was awarded the
Wolf Prize in Medicine. ==Awards and recognition==