At age 20, Sano submitted her comics to three publishers, receiving a reply from Tatsuya Shiode, an editor for the magazine
Harta (formerly named
Fellows!). Her next one-shot ''Taylor's House
was released in Fellows!'' that year. Sano's debut series was originally planned to be a "romantic comedy about [a] boy who can see the five seconds into the future, and how he falls in love with other girls." It revolves around a high school student named Sakamoto who has a reputation for being the "coolest" person in the entire student body. The series won the
Comic Natalie Grand Prize in 2013 and was nominated for the
Manga Taishō in 2014.
Studio Deen adapted the manga into an
anime series in 2016; a spin-off one-shot titled
A.K.A. 8823 was published in
Harta in the same year. Sano was a special guest at
Anime Expo 2016 where she held autograph sessions. It follows the titular twins Migi and Dali who pose as a boy named Hitori while finding out the truth surrounding their mother's death. Seven volumes were released, which have a total of 350,000 copies in circulation. It was adapted into an anime series by
Geek Toys and CompTown in 2023. Sano drew the illustrations shown in the anime's ending sequence; they were later included in a 28-page booklet titled
The Timeless Collection of Arts from "Migi & Dali" that was bundled with an issue of
Harta. Sano finished supervising the adaptation prior to her death. ==Death==