Talese began her career at
Random House, first as a proofreader and later as the publisher's first female literary editor. She later worked at
Simon & Schuster and
Houghton Mifflin. Talese has edited many notable authors, including
Pat Conroy,
Margaret Atwood,
Deirdre Bair,
Ian McEwan,
Jennifer Egan,
Antonia Fraser,
Barry Unsworth,
Valerie Martin, and
Thomas Keneally. Talese's imprint published
James Frey's fabricated memoir,
A Million Little Pieces. In 2006, Talese published a small edition of mostly blank pages under the title of
Useless America by
Jim Crace, whose book
The Pesthouse was forthcoming from her imprint but which did not yet have a title.
Useless America was inspired by a "phantom" book of Crace's which had been listed on Amazon in error. The title came from the line "This used to be America", which Crace had planned to use to begin
Pesthouse. The book, now scarce, commands a high resale value. ==Personal life==