Sharpless was involved in research studying the role of neurotransmitter amines in brain function, as well as investigating changes in neurotransmitter amine metabolism in fluctuations of mood and behavior as well as various neurological and mental disorders. Sharpless authored over fifty research articles and eleven book chapters on the measurement of neurotransmitters, metabolism and mental disorders, and using animal models of neurological disorders. She served as president of the Foundation for Science and the Handicapped. She was also a board member for the
Alexander Graham Bell Association for the Deaf and Hard of Hearing. Sharpless encouraged deaf people to consider scientific research as a career in a paper presented at the
American Association for the Advancement of Science meeting in 1975. Wayne State University recognized her with their Distinguished Alumni Award in 1980. Sharpless died October 9, 1987, in New York City. ==References==